摘要  目的  探讨伊贝沙坦治疗轻、中度原发性高血压的疗效。方法  96例轻、中度原发性高血压患随机分为两组：伊贝沙坦组（56例）150～300mg/d口服，氨氯地平组（40例）５mg/d口服，疗程均为8周，治疗前、治疗后4周和8周行动态血压监测。  结果  在疗程第4周和第8周伊贝沙坦和氨氯地均有较好的降压效果，两组间血压下降差别无统计学意义，第8组伊贝沙坦组总有效率为71.6，氨氯地平组为68.2，两组用药耐受性良好，氨氯地平组与用药相关的水肿发生率略高。结论  伊贝沙坦对高血压有确切疗效，且耐受性良好，无特征性毒副作用。[关键词]  伊贝沙坦；氨氯地平；原发性高血压Efficacy of irbesartan in the treatment of essential hypertension.Chen Jin-liang Li Xian-ping^* Liu Bao-guo^* Chai Xi-qing^* Guo Pei-ying(Departmet of Cardiology Handan Railway Hospital Handan China 056001 *Handan Medical College Affillated Hospital Handan China 056002)ABSTRACT  Objective To investigate the efficacy of irbesartan in the treatment of essential hypertension. Method  96